A ample UK Biobank study reveals that simply picking up your stepping gait could beryllium a powerful, low-cost measurement to protect bones and forestall fractures, sloppy of your familial risk.
Study: Walking gait and its relation pinch osteoporosis and pathological fractures: insights from UK biobank. Image credit: PeopleImages.com - Yuri A/Shutterstock.com
A caller study successful Frontiers successful Endocrinology examined nan relation betwixt osteoporosis and accustomed stepping pace, and considered imaginable interactions pinch familial vulnerability.
Walking habits and communal age-related diseases
Osteoporosis is characterized by reduced bony mineral density (BMD), accrued fracture susceptibility, and microarchitectural deterioration. UK information showed that astir 2.8 cardinal individuals aged 50 and supra suffered from osteoporosis successful 2017. Given nan rising economical and wellness load posed by osteoporosis, it is basal to create prevention strategies.
While existing investigation has highlighted nan beneficial domiciled of expanding beingness activity successful reducing osteoporosis rates and maintaining BMD, it predominantly considers guidance training and high-intensity activities. The existing lit indicates that stepping gait is informative, arsenic it tin thief foretell nan early prevalence of definite diseases successful a population.
Walking gait is besides intimately related to galore communal diseases. A brisk stepping gait is associated pinch a little consequence of chronic obstructive pulmonary illness (COPD), type 2 glucosuria (T2D), bosom failure, and Alzheimer’s disease. Conversely, a slow stepping gait is associated pinch a higher consequence of these diseases.
In patients pinch Parkinson’s disease, brisk stepping has been shown to heighten cognitive function. These findings propose a imaginable narration betwixt aging-related diseases and stepping pace. Specifically, location is constricted investigation connected nan relation betwixt osteoporosis, a communal age-related condition, and stepping pace.
About nan study
The existent study utilized information from 348,334 UK Biobank participants to analyse nan nexus betwixt stepping pace, estimated bony mineral density (eBMD, measured utilizing bottommost ultrasound alternatively than DXA), and osteoporosis and measure nan relationship betwixt familial susceptibility to osteoporosis and stepping pace.
Data connected participants, predominantly betwixt 40 and 69 years old, were collected. The cardinal variables of liking were accustomed stepping pace, BMD, osteoporosis incidence, and familial vulnerability. A stepping velocity of nether 3 miles per hr was characterized arsenic a slow stepping pace, betwixt 3 and 4 miles per hr was considered a normal pace, while exceeding 4 miles per hr was considered a brisk pace.
Data connected covariates, including demographic, socioeconomic, lifestyle, and familial factors, were besides collected. A operation of Cox proportional hazards regression models, linear regressions, and stratified study methods was utilized to measure nan correlations.
Study findings
The sample's slow, normal, and brisk gait were 6.5%, 52.8%, and 40.7%, respectively. Participants successful nan slow gait class were much apt to beryllium female, older, of non-European ethnicity, pinch little acquisition attainment, higher assemblage wide scale (BMI), little beingness activity, higher smoking rates, and little intoxicant depletion than nan normal gait group. The baseline characteristics of nan study organization successful nan brisk gait group were precisely other to those of nan slow gait group.
The aggregate linear regression study showed that a slower stepping gait was associated pinch little BMD, while nan effects were other for brisk walking. Relative to normal pace, location was a importantly higher relationship betwixt osteoporosis and slow stepping pace, arsenic evidenced by nan results from nan binary logistic regressions. On nan contrary, a brisk stepping gait correlated pinch a reduced likelihood of osteoporosis.
Over nan full follow-up duration, aft adjusting for BMI, age, and sex, a important relationship was noted betwixt a heightened consequence of osteoporosis and fractures and a slower stepping pace. Conversely, a little consequence of osteoporosis and fracture was associated pinch brisk stepping pace.
For example, compared pinch normal pace, slow walkers had astir 2.18 times higher consequence of osteoporosis and 2.25 times higher consequence of fractures, while brisk walkers had a 13-25% little risk. The affirmative relation betwixt osteoporosis consequence and stepping gait was not modified by excluding individuals pinch a baseline history of osteoporosis for 2 years aliases more.
Sub-group study showed that males had a stronger relation betwixt stepping gait and osteoporosis than females. The adverse effects of slow stepping were stronger successful individuals pinch normal and underweight BMI, comparative to overweight and obese subgroups. The narration betwixt stepping gait and osteoporosis consequence remained akin crossed groups created by beingness activity, smoking, and intoxicant consumption.
The study recovered a important relationship betwixt familial susceptibility and stepping gait concerning osteoporosis risk. Among individuals pinch little familial predisposition, slow walkers had a higher consequence of osteoporosis, while brisk walkers had a little consequence than those stepping normally. Conversely, successful nan precocious familial predisposition group, nan effects of osteoporosis consequence were little pronounced for slow and brisk walkers.
Notably, nan study recovered that stepping gait remained an independent predictor of osteoporosis consequence sloppy of familial background.
Conclusions
The results show a adjacent relation betwixt stepping gait and osteoporosis and fracture incidence risk. Therefore, encouraging individuals to locomotion astatine an elevated gait could assistance successful nan prevention of osteoporosis.
A cardinal limitation of nan study is that it only establishes correlations and does not shed ray connected nan causal mechanisms. As stepping gait was self-reported, measurement variability and callback bias could besides exist. In addition, nan dataset lacked accusation connected fracture sites, limiting site-specific conclusions.
Download your PDF transcript now!
Journal reference:
- Hu, Q. et al. (2025). Walking gait and its relation pinch osteoporosis and pathological fractures: Insights from UK biobank. Frontiers successful Endocrinology. 16, 1635999. https://doi.org/10.3389/fendo.2025.1635999. https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1635999/full