Underactive Thyroid Linked To Increased Risk Of Small Intestinal Bacterial Overgrowth

4 days ago

People pinch an underactive thyroid whitethorn person an accrued consequence of processing mini intestinal bacterial overgrowth (SIBO), a consequence that whitethorn beryllium reduced pinch thyroid hormone treatment, according to a study being presented Saturday astatine ENDO 2025, nan Endocrine Society's yearly gathering successful San Francisco, Calif.

We now cognize that group pinch hypothyroidism, particularly those pinch autoimmune thyroiditis, are much apt to create SIBO, but this consequence look to beryllium mitigated successful those taking thyroid medications."

Ruchi Mathur, M.D., Director of nan Diabetes Outpatient Treatment and Education Center and Director of Clinical Operations of Medically Associated Science and Technology, astatine Cedars-Sinai successful Los Angeles, Calif.

Mathur said their investigation besides suggests location whitethorn beryllium a microbiological system driving this association, which could lead to much personalized treatments.

The researchers investigated nan narration betwixt SIBO and hypothyroidism successful group older than 18 who antecedently underwent precocious endoscopy without colon prep and reported surviving pinch hypothyroidism arsenic good arsenic controls. Subjects were recruited done their flagship REIMAGINE study.

They analyzed mini bowel fluid samples from 49 group pinch hypothyroidism and 323 without nan information and performed DNA sequencing to place microbial species. The results showed that group pinch hypothyroidism had a importantly higher prevalence of SIBO compared to controls (33% vs. 15%).

Mathur and colleagues past further evaluated 4 groups: SIBO-positive pinch hypothyroidism, SIBO-negative pinch hypothyroidism, SIBO-positive without thyroid disease, and SIBO-negative without thyroid disease.

The study showed different patterns of germs successful nan gut depending connected a person's thyroid position and co-occurrence of SIBO.

Separately, they performed a large-scale study of aesculapian records from nan TriNetX database, which looked astatine nan 10-year risks of processing SIBO successful group pinch hypothyroidism aliases autoimmune thyroiditis compared to matched controls. The risks were besides mitigated successful group taking levothyroxine.

"Results showed nan consequence of processing SIBO successful subjects pinch hypothyroidism is 2.2 times much than nan consequence successful a matched power cohort and was 2.4 times higher successful those pinch autoimmune thyroiditis compared to a matched power group. This echoes our findings successful nan REIMAGINE cohort," noted nan study's presenting author, Margaret Wei, M.D., of nan Cedars-Sinai Medical Center Endocrine Fellowship Program.

"These findings unfastened nan doorway to caller screening and prevention strategies. For example, doctors whitethorn statesman to show thyroid wellness much intimately successful patients pinch SIBO, and vice versa. It besides supports nan thought that improving gut wellness could person far-reaching effects beyond digestion, perchance moreover helping to forestall autoimmune diseases, specified arsenic Hashimoto's," Mathur said. "As investigation continues, this could lead to much personalized attraction and earlier interventions for at-risk individuals."

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