Over nan past 50 years, rates of obesity and type-2 glucosuria person soared, while sperm value has plummeted. Driving these changes could beryllium nan expanding fame of ultra-processed foods, which person been linked to a scope of mediocre wellness outcomes. However, scientists still aren't judge whether it's nan business quality of nan ingredients themselves, nan processing of nan foods, aliases whether it's because they lead group to eat much than they should.
An world squad of scientists has now discovered that group summation much weight connected an ultra-processed fare compared to a minimally processed diet, moreover erstwhile they eat nan aforesaid number of calories. The study successful humans besides revealed a fare precocious successful ultra-processed foods introduces higher levels of pollutants that are known to impact sperm quality. The findings were published successful nan journal Cell Metabolism.
"Our results beryllium that ultra-processed foods harm our reproductive and metabolic health, moreover if they're not eaten successful excess. This indicates that it is nan processed quality of these foods that makes them harmful," says Jessica Preston, lead writer of nan study, who carried retired nan investigation during her PhD astatine nan University of Copenhagen's NNF Center for Basic Metabolic Research (CBMR).
Same calories, different outcomes
To get nan champion imaginable data, nan scientists compared nan wellness effect of unprocessed and ultra-processed diets connected nan aforesaid person. They recruited 43 men aged 20 to 35, who spent 3 weeks connected each of nan 2 diets, pinch 3 months 'washout' successful between. Half started connected nan ultra-processed and half started connected nan unprocessed diet. Half of nan men besides received a high-calorie fare pinch an other 500 regular calories, while half received nan normal magnitude of calories for their size, property and beingness activity levels. They were not told which fare they were on. Both nan unprocessed and ultra-processed diets had nan aforesaid magnitude of calories, protein, carbs and fats.
Men gained astir 1 kg much of fat wide while connected nan ultra-processed fare compared to nan unprocessed diet, sloppy of whether they were connected nan normal aliases excess calorie diet. Several different markers of cardiovascular wellness were besides affected.
Ultra-processed foods polluted pinch endocrine disruptors
The scientists besides discovered a worrying summation successful nan level of nan hormone-disrupting phthalate cxMINP, a constituent utilized successful plastics, successful men connected nan ultra-processed diet. Men connected this fare besides saw decreases successful their levels of testosterone and follicle-stimulating hormone, which are important for sperm production.
We were shocked by really galore assemblage functions were disrupted by ultra-processed foods, moreover successful patient young men. The semipermanent implications are alarming and item nan request to revise nutritional guidelines to amended protect against chronic disease."
Professor Romain Barrès, study's elder author from nan University of Copenhagen's NNF Center for Basic Metabolic Research, and nan Université Côte d'Azur
Source:
Journal reference:
Preston, J. M., et al. (2025). Effect of ultra-processed nutrient depletion connected antheral reproductive and metabolic health. Cell Metabolism. doi.org/10.1016/j.cmet.2025.08.004