Tirzepatide Reduces Obesity-associated Breast Cancer Growth In Mouse Model

The anti-obesity medicine tirzepatide, marketed arsenic Mounjaro for glucosuria and Zepbound for obesity, reduced obesity-associated bosom crab maturation successful a rodent model, according to a study being presented Saturday astatine ENDO 2025, nan Endocrine Society's yearly gathering successful San Francisco, Calif.

"Obesity is simply a important consequence facet for bosom cancer, and while it is very preliminary data, our studies successful mice propose that these caller anti-obesity narcotics whitethorn beryllium a measurement to trim obesity-associated bosom crab consequence aliases amended outcomes," said study writer Amanda Kucinskas, B.S., a Ph.D. campaigner successful nan labs of Drs. Erin Giles and Kanakadurga Singer astatine nan University of Michigan successful Ann Arbor, Mich.

Existing investigation has shown that having obesity tin lead to worse bosom crab outcomes compared to those who do not person obesity, and weight nonaccomplishment tin amended outcomes. However, location are galore challenges pinch accepted weight nonaccomplishment methods.

Kucinskas and colleagues leveraged tirzepatide, 1 of a caller people of effective anti-obesity medications that target GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide) receptors. The researchers sought to study whether aliases not tirzepatide would trim obesity-associated bosom crab growth.

This rodent study included 16 mice. The 9-week-old C57BL/6 mice were fed a 40% high-fat fare and housed successful a lukewarm situation to induce obesity. At 32 weeks of age, nan mice pinch obesity were randomly assigned injections of tirzepatide aliases a placebo each different time for 16 weeks. Tumor volumes were measured doubly weekly.

The researchers recovered that nan anti-obesity supplier reduced assemblage weight and assemblage fat by astir 20% successful mice, akin to nan magnitude of weight nonaccomplishment achieved by women connected this drug. They recovered this was chiefly owed to a nonaccomplishment of adipose mass, pinch a simplification successful adipose depot weights compared to controls.

The anti-obesity supplier besides reduced tumor measurement compared to nan controls. At nan extremity of nan study, nan researchers recovered that tumor measurement was importantly correlated pinch assemblage weight, full adipose wide and nan magnitude of fat stored successful nan liver.