Shared Gene Signatures Reveal Metabolic Dysfunction In Liver Cirrhosis And Acute-on-chronic Liver Failure

Background and objectives

Chronic liver cirrhosis (LC) and acute-on-chronic liver nonaccomplishment (ACLF) are interconnected hepatic disorders associated pinch important morbidity and mortality. Despite their chopped objective characteristics, some conditions stock communal pathogenic pathways that stay inadequately understood. This study aimed to place shared cistron signatures and elucidate underlying molecular mechanisms.

Methods

In this study, we employed Weighted Gene Co-Expression Network Analysis to research transcriptomic information from nan Gene Expression Omnibus for LC and ACLF.

Results

Key co-expression modules enriched pinch genes progressive successful glycolysis and gluconeogenesis pathways were identified, implicating metabolic dysfunction arsenic a cardinal characteristic successful some conditions. Furthermore, microRNA study revealed that hsa-miR-122 and hsa-miR-194 play pivotal roles successful regulating these metabolic pathways, perchance contributing to immune dysregulation.

Conclusions

Our transcriptomic study has uncovered a imaginable pathogenic relation betwixt glucose metabolism and some ACLF and LC. This relation is mediated by miR-122 and miR-194, on pinch their corresponding signaling pathways. These findings item caller therapeutic targets that warrant further in-depth exploration.