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2 days ago
Not each acute myocardial infarction patients should beryllium offered regular screening for nan tummy ulcer bacterium Helicobacter pylori. However, it is imaginable that immoderate diligent groups pinch an elevated consequence of post-infarction gastrointestinal bleeding use from specified a test, concludes a large-scale study from Karolinska Institutet and Södersjukhuset successful Sweden published successful nan diary JAMA.
Upper gastrointestinal bleeding is simply a superior complication that affects astir 2 per cent of patients wrong a twelvemonth of a myocardial infarction.
It's associated pinch accrued mortality and nan consequence of recurring cardiovascular events. We truthful wanted to analyse if screening for nan communal Helicobacter pylori bacterium, which causes gastritis and gastric ulcers, tin trim nan consequence of bleeding. This is presently not regular practice."
Robin Hofmann, study's lead author, elder advisor astatine nan Department of Cardiology, Södersjukhuset, and subordinate professor astatine nan Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet
The randomized study included almost 18,500 myocardial infarction patients astatine 35 hospitals successful Sweden. Half nan group was tested for nan bacterium and treated pinch antibiotics and macromolecule pump inhibitors by their doctors if testing positive, while nan different half received regular attraction without an other trial aliases treatment.
Effective successful patients pinch anemia
After almost 2 years' follow-up, nan researchers recovered that location were somewhat less individuals successful nan screening programme who had suffered gastrointestinal bleeding, but not capable to make nan quality statistically significant. However, they recovered a affirmative effect of nan screening erstwhile studying circumstantial sub-groups of patients, specified arsenic those pinch anaemia aliases kidney failure. A peculiarly affirmative effect was observed successful patients pinch mean to terrible anaemia, who suffered gastrointestinal bleeding astatine astir half nan complaint if they underwent screening.
"Our results propose that screening for Helicobacter pylori does not request to beryllium done routinely for each individuals pursuing a bosom attack," says Dr Hofmann. "On nan different hand, testing and curen could beryllium a meaningful complement for selected diligent groups pinch an elevated consequence of bleeding."
The researchers will now spell connected to study nan semipermanent effects and effort to place which groups will use astir from screening.
The study was conducted successful collaboration pinch Södersjukhuset, Region Stockholm and nan Uppsala Clinical Research Centre (UCR), and was financed chiefly by nan Swedish Research Council, nan Swedish Heart Lung Foundation and Region Stockholm.
Source:
Journal reference:
Hofmann, R., et al. (2025). Helicobacter pylori Screening After Acute Myocardial Infarction. JAMA. doi.org/10.1001/jama.2025.15047
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