Research Warns Of Lasting Health Impacts From Muscle Loss In Young Cancer Patients

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New investigation from nan Exercise Medicine Research Institute astatine Edith Cowan University (ECU) has highlighted that children undergoing crab curen often suffer skeletal musculus astatine a clip erstwhile they should beryllium quickly gaining it, a nonaccomplishment that could summation curen complications and raise nan consequence of semipermanent wellness problems. 

Both nan crab itself and nan crab curen tin origin musculus nonaccomplishment successful children. 

Muscle is nan body's metabolic reserve. When children suffer musculus during treatment, they tolerate chemotherapy little good and look a higher consequence of complications from supplier toxicity." 

Anna Maria Markarian, ECU PhD student 

Losing musculus besides makes children and adolescents much susceptible to bosom and metabolic problems specified arsenic precocious humor sweetener and insulin resistance, Ms Markarian said. 

"For example, during nan onset of puberty children summation 3 kg to 5 kg of musculus per year. If curen interrupts this maturation and it isn't recovered afterwards, it tin severely effect wellness outcomes successful nan longer term." 

The investigation besides recovered that children undergoing crab curen are apt to acquisition increases successful fat mass, which tin further lend to metabolic problems and summation nan consequence of heart-related issues. 

"Weight is not nan full story. Two kids tin measurement nan same, 1 pinch patient muscle, 1 pinch excess fat, and their expertise to tolerate chemotherapy could beryllium very different. 

"The situation present is differentiating betwixt musculus nonaccomplishment and fat gain, arsenic this could person important objective implications. Shifts successful assemblage creation tin create a mismatch betwixt dosing assumptions and existent metabolic capacity, heightening nan consequence of treatment-related complications and poorer objective outcomes successful patients pinch diminished skeletal musculus mass," Ms Markarian said. 

The connection for parents is simple: support kids moving. Encourage age-appropriate progressive play and exercise, contempt nan evident difficulties that would beryllium associated pinch that. 

Source:

Journal reference:

Markarian, A. M., et al. (2025). Longitudinal changes successful skeletal musculus successful children undergoing crab treatment: a systematic reappraisal and meta-analysis. European Journal of Pediatrics. doi.org/10.1007/s00431-025-06349-5

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