Novel Polysaccharide From Albizzia Julibrissin Shows Promise Against Pancreatic Cancer

Albizzia julibrissin is simply a wide distributed works successful China. Its dried stem bark has been utilized successful accepted oriental medicine to dainty insomnia, diuresis, sthenia, ascaricide, and confusion. Phytochemical investigations connected nan components of nan stem bark of Albizzia julibrissin resulted successful nan isolation of saponins, lignans, phenolic glycosides, triterpenes, flavonoids, and others. The bioactive ingredients from Albizzia julibrissin person been reported for their medicinal activities specified arsenic anti-tumor, inhibitory effect of diarrhoea, and a sedative activity. Nonetheless, to date, lit connected polysaccharide arsenic an important constituent of Chinese herbal remains scarce, peculiarly successful nan lawsuit of polysaccharide successful Albizzia julibrissin.

In nan caller study published successful Glycoscience & Therapy, a squad of researchers successful China extracted a caller polysaccharide fraction, AJDW, from Albizia julibrissin (AJD). It is composed of glucose, galactose, xylose, arabinose (with a molar ratio of 7.36: 9.03: 7.06: 2.24: 1).

Pancreatic crab is simply a fatal malignant tumor pinch mediocre prognosis, and astir of nan existent chemotherapeutic agents are prone to supplier guidance and person utmost broadside effects. Many studies person reported that polysaccharides tin exert effective anti-tumor activity and person a promising safety. Hence, nan find of polysaccharides pinch anti-pancreatic crab activity is successful objective demand.

"In our work, patient-derived xenografted mice exemplary was constructed, and AJDW would wholly impede pancreatic crab maturation successful nude mice, which was matched pinch nan anti-pancreatic crab activity successful cellular level." Adds She. "Our findings not only showed nan caller polysaccharide compound successful Chinese herbal AJD, but besides revealed its anti-pancreatic crab effect."

This find provides nan worldly and theoretical ground for nan imaginable anti-tumor effect of AJD, further facilitating nan improvement of caller anti-pancreatic crab narcotics based connected earthy ingredients.

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Journal reference:

Xiao, R., et al. (2025). AJDW, polysaccharide from Albizia julibrissin, binds to PI3K and induces compartment rhythm apprehension and ROS-mediated pancreatic crab compartment apoptosis. Glycoscience & Therapy. doi.org/10.1016/j.glycos.2025.100003.