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Epilepsy affects complete 70 cardinal group worldwide, and a important information of patients suffer from drug-resistant epilepsy (DRE), wherever modular medications fail. Beyond nan seizures themselves, galore patients look a hidden but devastating burden: cognitive decline, including representation nonaccomplishment and trouble concentrating. These symptoms are believed to stem from underlying inflammation and structural encephalon damage. The ketogenic fare (KD) has agelong been utilized to negociate seizures successful DRE, but its imaginable to protect encephalon usability remains underexplored. Due to these challenges, researchers are turning their attraction toward knowing really KD mightiness sphere cognitive abilities by addressing nan guidelines causes of neurological decline.
A investigation squad astatine nan Children's Hospital of Chongqing Medical University has published a study (DOI: 10.1002/pdi3.70013) successful Pediatric Discovery (June 23, 2025), revealing really nan KD tin reconstruct cognitive usability pursuing position epilepticus. The scientists utilized a well-established rat exemplary to analyse changes successful memory, behavior, encephalon structure, and inflammation. Central to their investigation was nan NF-κB pathway—a maestro move for inflammation successful nan brain—aiming to uncover whether KD's protective effects are tied to suppression of this pathway and its downstream inflammatory responses.
In nan study, juvenile rats were induced pinch SE utilizing pilocarpine and past divided into groups, pinch immoderate receiving a KD for either 7 aliases 20 days. The researchers conducted a bid of behavioral tests, including nan Morris h2o maze and Y-maze, to measure representation and spatial learning. Rats fed pinch KD demonstrated notable improvements successful exploratory behaviour and cognitive capacity compared to their non-treated counterparts.
Microscopic study revealed that KD-fed rats showed importantly little harm successful nan hippocampus—a encephalon region basal for memory. Neuronal density, myelin integrity, and axonal building were each amended preserved. This structural protection correlated pinch reduced levels of proinflammatory cytokines (IL-1β, IL-6, TNF-α).
Molecular studies confirmed that KD suppressed activation of nan NF-κB pathway, evident done decreased atomic translocation of NF-κB p65 and reduced phosphorylation of IκB. These changes propose that KD not only reduces inflammation but interrupts its signaling astatine nan source. Together, nan findings exemplify a two-pronged benefit: restoring representation and repairing encephalon damage—both mediated by curbing inflammation astatine nan molecular level.
Our investigation highlights a captious displacement successful really we position nan KD—not conscionable arsenic a seizure-control therapy, but arsenic a powerful instrumentality for encephalon repair. By dialing down inflammation astatine nan cellular level, KD helps nan encephalon retrieve from nan semipermanent consequences of seizures. These results unfastened up caller possibilities for non-drug therapies that reside some nan seizures and nan silent harm they time off behind. The early of epilepsy curen whitethorn dishonesty successful nan synergy of metabolic and molecular interventions."
Dr. Xiaojie Song, corresponding writer of nan study
These findings connection breathtaking possibilities for expanding nan domiciled of nan KD successful neurological care. Beyond epilepsy, KD could look arsenic a valuable involution for different encephalon disorders marked by inflammation and cognitive decline, specified arsenic Alzheimer's illness and traumatic encephalon injury. The expertise to modulate nan NF-κB pathway done dietary intends opens a doorway to low-risk, non-invasive therapeutic strategies. Future investigation will request to research really agelong these benefits last, nan perfect long of treatment, and whether combining KD pinch pharmacological agents could further amplify its effects—especially successful susceptible populations for illustration children pinch DRE.
Source:
Journal reference:
Wang, W., et al. (2025). Protective Effects of nan Ketogenic Diet connected Cognitive Impairment Induced by Status Epilepticus successful Rats: Modulation of Neuroinflammation Through nan NF‐κB Signaling Pathway. Pediatric Discovery. doi.org/10.1002/pdi3.70013.
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