"Pharmacotherapy tin thief group surviving pinch obesity amended wide health, not conscionable suffer weight," says Dr. Sue D. Pedersen, MD, endocrinologist and obesity medicine master successful Calgary, and lead writer of this guideline. "The extremity of obesity medications is to amended metabolic, mechanical, and/or intelligence health, and amended value of life, incorporating curen goals that are important to each individual patient."
The line includes 6 caller and 7 revised recommendations, reflecting nan latest grounds since nan 2022 and 2020 versions of nan guideline. It takes nan accent disconnected assemblage wide scale (BMI) and focuses connected an individualized attack that uses further indicators, specified arsenic waist circumference, waist-to-hip ratio, waist-to-height ratio, adjusted for activity and ethnicity wherever appropriate, and nan beingness of obesity-related complications.
Obesity pharmacotherapy is simply a safe and effective action to support semipermanent obesity care. It is 1 of 3 pillars of curen outlined successful nan afloat Canadian Adult Obesity Clinical Practice Guideline, pinch different pillars being behavioural and psychological and surgical approaches. Obesity curen should ever beryllium tailored to each person's circumstantial wellness needs, values, and preferences. Recommendations besides support sustained usage of obesity pharmacotherapy arsenic portion of a semipermanent strategy to support improvements successful wellness and value of life."
Dr. Sue D. Pedersen, MD, endocrinologist and obesity medicine master successful Calgary
Recommendations see 2 caller medications, tirzepatide and setmelanotide, arsenic good arsenic caller recommendations for obesity-related complications specified arsenic atherosclerotic cardiovascular disease, bosom nonaccomplishment pinch preserved ejection fraction, osteoarthritis, and more.
The line recommends against utilizing compounded obesity medications because of concerns astir content, safety, efficacy, and quality.
The line sheet notes that only Alberta recognizes obesity arsenic a chronic disease. Barriers to entree - specified arsenic cost, stigma, and constricted supplier scheme sum - proceed to forestall Canadians from receiving medicine and support.
"The deficiency of nickname of obesity arsenic a chronic illness by nationalist and backstage payers, wellness systems, nan public, and media has a trickle-down effect, limiting entree to curen (e.g., related to medicine costs)," nan authors conclude.
Source:
Journal reference:
Pedersen, S. D., et al. (2025) Pharmacotherapy for obesity guidance successful adults: 2025 objective believe line update. CMAJ. doi.org/10.1503/cmaj.250502.