.png?2.1.1 "Vokash")
2 days ago
Prostate crab is highly heterogeneous, ranging from slow-growing tumors to aggressive, life-threatening disease. Current diagnostic methods, specified arsenic prostate-specific antigen (PSA) testing and integer rectal examination, person important limitations: PSA levels tin emergence owed to benign conditions, while Gleason scoring of biopsies is subjective and prone to misclassification. These challenges lead to predominant overdiagnosis and overtreatment, arsenic good arsenic missed discovery of fierce tumors. Researchers person truthful turned to molecular biomarkers to capable nan diagnostic gap. MicroRNAs, which are unchangeable successful tissues and assemblage fluids, connection a promising noninvasive alternative. Due to these challenges, location is an urgent request to behaviour deeper investigation connected microRNA panels for prostate crab diagnosis.
A reappraisal (DOI: 10.1002/uro2.105) published successful UroPrecision (February 2025) by researchers from King George's Medical University, India, brings caller insights into nan diagnostic imaginable of microRNA panels for prostate cancer. The article synthesizes world studies demonstrating really combinations of microRNAs, identified successful insubstantial and liquid biopsies, tin enactment arsenic reliable biomarkers. By providing higher specificity and sensitivity than accepted tests, these panels could support much meticulous consequence assessment, early detection, and personalized curen strategies for men pinch prostate cancer.
The reappraisal summarizes extended grounds showing that azygous microRNAs often deficiency nan robustness to service arsenic independent biomarkers, but panels combining respective microRNAs markedly amended diagnostic accuracy. In coagulated biopsies, panels specified arsenic miR-17-3p, miR-27a-3p, miR-200a-3p, miR-375, and miR-376b-3p person shown beardown predictive powerfulness for metastasis (AUC up to 89.5%). Similarly, four-microRNA models including miR-23a-3p, miR-10b-5p, miR-133a-3p, and miR-374b-5p were validated arsenic prognostic markers for biochemical recurrence.
Liquid biopsy investigation further strengthens their promise. Panels detected successful serum, plasma, and urine—such arsenic miR-146a-5p, miR-24-3p, and miR-93-5p—have achieved diagnostic accuracies supra 80%. Others, for illustration miR-141, miR-151-3p, and miR-16 mixed pinch PSA levels, demonstrated near-perfect sensitivity and specificity (AUC 0.968). Urinary exosome-derived microRNA panels person moreover reached 100% sensitivity and specificity successful distinguishing prostate crab from benign prostatic hyperplasia and patient controls.
The reappraisal besides explores nan interplay betwixt microRNAs and information RNAs, which enactment arsenic "sponges" regulating tumor pathways. These networks whitethorn uncover caller therapeutic targets, underscoring that microRNA panels are not conscionable diagnostic devices but besides keys to knowing illness progression.
MicroRNA panels correspond 1 of nan astir breathtaking frontiers successful precision oncology. Their stableness successful assemblage fluids, coupled pinch their expertise to seizure nan complexity of prostate crab biology, makes them perfect candidates for noninvasive diagnostics. What is peculiarly encouraging is nan consistency of results crossed divers populations and sample types, from humor to urine. As validation expands, these biomarkers could go portion of regular objective practice, importantly reducing misdiagnosis and improving diligent outcomes".
Dr. Mohammad Kaleem Ahmad, elder writer of nan review
The objective exertion of microRNA panels could toggle shape prostate crab guidance by enabling earlier and much meticulous discovery while sparing patients from unnecessary invasive procedures. Incorporating these biomarkers into screening programs whitethorn thief differentiate indolent from fierce cancers, guiding curen choices much precisely. Beyond diagnostics, integrating microRNA profiles pinch bioinformatics could illuminate caller therapeutic pathways, offering caller supplier targets. With their scalability successful liquid biopsy tests, microRNA panels clasp committedness for wide population-level screening and personalized medicine, perchance reshaping world strategies for prostate crab prevention, monitoring, and therapy successful nan coming decade.
Source:
Journal reference:
Manoj, A., et al. (2025). Unveiling nan imaginable of emerging microRNA panels arsenic diagnostic biomarkers for prostate cancer: A review. UroPrecision. doi.org/10.1002/uro2.105
English (US) · 
Indonesian (ID) ·