Low Fodmap Diet Increases Glp-1 And Relieves Ibs Symptoms

A 12-week debased FODMAP fare not only eased pain, bloating, and diarrhea successful IBS patients but besides raised levels of nan gut hormone GLP-1. However, nan hormone displacement didn’t afloat explicate nan denotation relief.

Study: Increase successful circulating GLP-1 pursuing debased FODMAP fare successful irritable bowel syndrome patients. Image credit: PeopleImages.com - Yuri A/Shutterstock.com

A fare that restricts nan intake of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) has been utilized to amended gut health. A caller study published successful Frontiers successful Nutrition highlights nan inferior of this fare successful managing symptoms of irritable bowel syndrome.

Background

Irritable bowel syndrome (IBS) is simply a communal multifactorial gastrointestinal information that importantly reduces nan wide value of life. Depending connected nan predominant symptoms, location are 4 types of IBS: IBS-diarrhea, IBS-constipation, IBS-mixed, and IBS-unspecified.

The intestinal hormone glucagon-like peptide 1 (GLP-1) is perchance associated pinch IBS pathophysiology. This hormone is secreted from nan intestine successful consequence to ingested nutrient and stimulates insulin merchandise from nan pancreas to trim humor glucose levels. It besides helps trim appetite, slow down gastric emptying, and induce weight loss.

The dietary intake of fermentable carbohydrates, including oligosaccharides, disaccharides, monosaccharides, and polyols, has been recovered to exacerbate IBS symptoms, and truthful a debased FODMAP fare has been recovered to amended IBS symptoms.

Given nan imaginable implications of some GLP-1 level and FODMAP intake successful IBS, researchers astatine nan Haukeland University Hospital, Norway, investigated nan effect of a debased FODMAP fare connected circulating GLP-1 levels successful patients pinch IBS-diarrhea and IBS-mixed.

Study design

The study included 30 big patients pinch mean to terrible diarrhea aliases mixed-type IBS. They followed a strict low-FODMAP fare for 12 weeks, guided by a registered dietitian, pinch monthly follow-ups to measure compliance and safety.

All participants were evaluated for IBS denotation severity, circulating GLP-1 levels, full FODMAP intake, and assemblage weight earlier and aft nan 12-week dietary intervention. This was a single-arm, pre-post interventional study without a power group for comparison.

Key findings

The study recovered a important simplification successful full FODMAP intake aft completing nan 12-week dietary intervention, indicating bully adherence to nan debased FODMAP diet. Dietary records were complete for 15 participants astatine some baseline and week 12, pinch further week 4 records supporting wide adherence.

Following a 12-week debased FODMAP fare intake, nan participants exhibited a important induction successful circulating GLP-1 levels (increasing modestly from astir 3.3 pM to 3.6 pM), importantly reduced assemblage weight, and importantly improved IBS and gastrointestinal symptoms. Improvements were seen successful pain, bloating, and diarrhea, while constipation and satiety symptoms did not alteration significantly.

The study could not find immoderate relationship betwixt changes successful GLP-1 levels and changes successful assemblage weight, IBS, aliases gastrointestinal symptoms.

Study significance

The study highlights nan benefits of a low-FODMAP fare successful managing diarrhea and mixed-type IBS. According to nan study findings, consuming a low-FODMAP fare for 12 weeks tin summation humor levels of GLP-1 and amended IBS symptoms.

Existing grounds indicates that circulating GLP-1 levels are positively associated pinch assemblage wide scale (a measurement of overweight aliases obesity) and that weight nonaccomplishment reduces circulating levels of GLP-1. However, nan existent study could not find immoderate relation betwixt circulating GLP-1 and assemblage weight changes, indicating that debased FODMAP diet-mediated changes successful GLP-1 levels are not solely owed to changes successful assemblage weight.

Similarly, nan study could not find immoderate relation betwixt changes successful circulating GLP-1 and changes successful IBS denotation severity, highlighting nan request for identifying underlying mechanisms driving these changes.

The observed changes successful GLP-1 level pursuing debased FODMAP fare intake mightiness beryllium explained by chemosensory mechanisms successful enteroendocrine cells progressive successful nutrient intake-mediated changes successful intestinal hormone levels. A debased FODMAP fare whitethorn change nan vulnerability of enteroendocrine cells to gut microbial metabolites, starring to altered accumulation of GLP-1.

Gut motility and intestinal obstruction integrity are 2 awesome components of IBS, which are affected by some FODMAPs and GLP-1. Therefore, an in-depth knowing of nan relation betwixt GLP-1 and a low-FODMAP fare has important therapeutic implications.

Both GLP-1 analogs and nan debased FODMAP fare person shown promising therapeutic outcomes successful patients pinch IBS. Existing grounds indicates that GLP-1 analogs thief trim symptom and power gut motility successful IBS patients. Similarly, a debased FODMAP fare has been recovered to impact gut motility and visceral hypersensitivity, which are basal aspects of nan brain-gut axis successful IBS.

This single-center study progressive only IBS patients; nary patient power group was included. Therefore, nan study could not show whether GLP-1 levels are different betwixt IBS patients and patient controls. Further studies are needed to comparison circulating GLP-1 levels successful different IBS subgroups and patient controls. Such studies could supply a much in-depth knowing of nan pathophysiological ground of nan alteration successful GLP-1 levels successful IBS.

Furthermore, this small-scale study assessed only a azygous dietary involution and recovered a important summation successful circulating GLP-1 levels. These findings supply a instauration for early studies to analyse nan effect of different dietary interventions connected enteroendocrine hormones.

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