Hpv16 And 18 Nearly Eliminated In Vaccinated Danish Women But Other High Risk Types Persist

Among nan much than 100 types of quality papillomavirus (HPV), astatine slightest 14 are considered arsenic 'high-risk' types which tin origin (cervical) cancer. After bosom cancer, cervical crab is nan astir communal crab successful Europe among women aged 15–44 years.

They tested up to 3 consecutive cervical compartment samples per subordinate provided by nan contributing pathology departments successful Denmark for HPV. In total, 17,252 women pinch astatine slightest 1 cervical compartment sample were registered betwixt 1 February 2017 and 29 February 2024. During nan 7 years of nan randomised "Trial23" study (cervical crab screening starts astatine property 23 successful Denmark), 84% of women successful nan study had astatine slightest 1 compartment sample taken. The authors compared HPV prevalence, persistence and incidence among vaccinated and unvaccinated women.

"Strong indication" of organization immunity against high-risk HPV types 16 and 18

Based connected nan information gathered during nan study period, HPV16/18 has been almost eliminated among vaccinated women successful Denmark: prevalence of these 2 types successful nan samples decreased to < 1% successful 2021 from 15–17% earlier vaccination of girls. In addition, prevalence of nan types 16/18 successful women who had not been vaccinated against HPV remained astatine 5% which, according to nan authors, "strongly indicates organization immunity".

Despite nan grounds of protection done vaccination, astir 1 3rd of women screened during nan study play still had HPV infection pinch high-risk HPV types not covered by nan offered vaccines - and caller infections pinch these types were much predominant successful vaccinated than successful unvaccinated women

There was a debased prevalence of HPV16/18 during nan 7-year study play and women who person been vaccinated against HPV arsenic girls are expected to person a considerably little consequence of cervical crab compared pinch erstwhile generations. Therefore, nan authors besides assessed whether nan existent cervical screening strategies successful nan state could beryllium adjusted accordingly aliases moreover stopped entirely.

The study results showed a remaining precocious prevalence of high-risk HPV infections successful women that are not covered by nan HPV vaccines and that had been detected some successful vaccinated and unvaccinated women during nan study period. At nan aforesaid time, nan authors noted a importantly higher incidence of non-vaccine high-risk HPV types among vaccinated women than successful unvaccinated women.

Based connected this, Nonboe et al. frankincense reason that "less intensive screening seems reasonable until women vaccinated arsenic girls pinch nan 9-valent vaccine scope screening age, astatine which constituent screening should beryllium reconsidered."