Fluorine-containing Medicines Do Not Increase Adverse Drug Reactions

Medicines containing a type of PFAS aliases 'forever chemical' called fluorine are not starring to higher numbers of adverse supplier reactions according to caller information analysis.

In a caller insubstantial published successful PLOS ONE today, researchers from nan University of Birmingham studied information from nan MHRA's Yellow Card strategy connected 13 narcotics containing carbon-fluorine bonds arsenic good arsenic six narcotics which were structurally akin but not containing this everlastingly chemical.

Using 5 years of information from 2019-2024, nan investigation squad analysed nan number of adverse supplier reactions (ADRs) per 1 cardinal medicines dispensed. They recovered that astir of nan ADRs that were listed for narcotics containing fluorine were associated pinch conditions extracurricular of nan scope of accustomed broadside effects from PFAS, and nan highest prescribed supplier lansoprazole, a proton pump inhibitor to trim tummy acid, had a debased complaint of 14.1 ADRs per 1m items.

Per- and poly-fluoroalkyl substances (PFAS) are often referred to arsenic "forever chemicals" owed to their persistence successful nan situation and effects connected quality health. PFAS are recovered successful a scope of mundane products specified arsenic cookware aliases clothing. Recent changes to nan classification of PFAS intends definite basal medicines are now deemed to incorporate everlastingly chemicals.

In this study we explored adverse supplier reactions reported to nan MHRA Yellow Card strategy comparative to their prescribing rate. Reassuringly, nary statistical relationship betwixt nan fluorine contented of nan medicine and type of broadside effect emerged."

Dr. Alan Jones, School of Pharmacy, University of Birmingham and corresponding writer of nan paper

Among nan 13 narcotics selected for study, nan squad observed nary narration betwixt nan magnitude of fluorine atoms successful nan medicine and nan number of ADRs reported. Among nan narcotics pinch nan highest level of fluorine, sitagliptin and flecainide didn't spot highest levels of reactions.

The squad besides looked astatine circumstantial types of ADRs crossed nan 13 fluorinated narcotics studied, and recovered that while reactions person been associated pinch PFAS-like broadside effects, nan comparison pinch non-fluorinated narcotics suggests that nan measurement nan supplier acted was much apt to consequence successful that ADR.

The researchers statement that limitations of nan study see nan self-reported quality of nan Yellow Card strategy which could lead to underreporting of adverse supplier reactions.