Deep-sea Bacterial Compound Triggers Pyroptosis To Fight Cancer

Promoting pyroptosis-an inflammatory shape of programmed compartment death-has go a promising curen strategy for cancer. In investigation published successful The FASEB Journal, investigators purified a long-chain sweetener molecule, aliases exopolysaccharide, from deep-sea germs and demonstrated that it triggers pyroptosis to inhibit tumor growth.

The compound, called EPS3.9, consists of mannose and glucose and is produced by nan Spongiibacter nanhainus CSC3.9 bacterial strain and different members of nan genus Spongiibacter. Mechanistic analyses showed that EPS3.9 tin straight target 5 membrane phospholipid molecules and exert tumor toxicity by stimulating pyroptosis successful quality leukemia cells. EPS3.9 besides had important anti-tumor effects successful nan mice pinch liver crab and activated anti-tumor immune responses.

Our activity not only provides a theoretical ground for processing much carbohydrate-based narcotics but besides highlights nan value of exploring marine microbial resources."

Chaomin Sun, PhD, corresponding author of nan Chinese Academy of Sciences