Commonly Used Type 2 Diabetes Medication Linked To Higher Rate Of Heart-related Conditions

New investigation from investigators astatine Mass General Brigham suggests that a commonly utilized type 2 glucosuria medicine is linked to a higher complaint of heart-related conditions compared to medications that deed different targets. The study examined nationwide information from astir 50,000 patients treated pinch different sulfonylureas and recovered that glipizide – nan astir wide utilized supplier successful nan U.S. wrong this class – was linked to higher incidence of bosom failure, related hospitalization and decease compared to dipeptidyl peptidase-4 (DPP-4) inhibitors. Results are published inJAMA Network Open.

Patients pinch type 2 diabetes are astatine heightened consequence of adverse cardiovascular incidents specified arsenic changeable and cardiac arrest. While sulfonylureas are celebrated and affordable glucosuria medications, location is simply a deficiency of semipermanent objective information connected really they impact cardiac wellness successful comparison to much neutral alternatives for illustration dipeptidyl peptidase 4 inhibitors."

Alexander Turchin, MD, MS, corresponding author of nan Division of Endocrinology astatine Brigham and Women's Hospital (BWH)

Turchin and co-authors emulated a target proceedings by analyzing physics wellness records and security claims information from nan BESTMED consortium. The cohort included 48,165 patients pinch type 2 glucosuria and mean cardiovascular consequence who received attraction astatine 10 different study sites crossed nan country, including BWH, arsenic good arsenic those covered by 2 different nationalist wellness security plans.

The researchers studied nan five-year consequence of awesome adverse cardiovascular events successful patients treated pinch different sulfonylureas (glimepiride, glipizide aliases glyburide) aliases DPP4i successful summation to metformin, a superior glucosuria medication. They recovered that glipizide was associated pinch a 13% summation successful cardiovascular consequence erstwhile compared to DPP4i, while glimepiride and glyburide led to comparatively smaller and little clear effects, respectively. The authors propose that further investigation is needed to uncover nan underlying mechanisms.

"Our study underscores nan value of evaluating each supplier successful a peculiar pharmacological people connected its ain merits," said Turchin.