Brain Cells Follow Rhythmic Patterns During Learning And Memory Retrieval

1 month ago

A investigation squad from nan University Hospital Bonn (UKB), nan University of Bonn, and nan Medical Center - University of Freiburg has gained caller insights into nan encephalon processes progressive successful encoding and retrieving caller representation content. The study is based connected measurements of individual nervus cells successful group pinch epilepsy and shows really they travel an soul rhythm. The activity has now been published successful nan diary Nature Communications.

"Similar to members of an orchestra who travel a communal beat, nan activity of nervus cells appears to beryllium linked to electrical oscillations successful nan brain, occurring 1 to 10 times per second. The cells for illustration to occurrence astatine circumstantial times wrong these encephalon waves, a arena known arsenic theta-phase locking," says first writer and postdoctoral interrogator astatine nan University of Bonn, Dr. Tim Guth, who precocious joined nan Cognitive and Translational Neuroscience group astatine nan UKB from nan Medical Center - University of Freiburg.

The investigation squad led by Tim Guth and Lukas Kunz recovered that nan relationship betwixt nervus cells and encephalon waves is progressive successful some nan learning and remembering of caller accusation - specifically successful nan medial temporal lobe, a cardinal area for quality memory. However, successful nan study connected spatial memory, nan spot of theta-phase locking of nervus cells during representation statement was independent of whether nan trial subjects were later capable to correctly callback nan representation content. "This suggests that theta-phase locking is simply a wide arena of nan quality representation system, but does not unsocial find successful recall," says corresponding writer Prof. Dr. Lukas Kunz, caput of nan Cognitive and Translational Neuroscience moving group astatine nan Clinic for Epileptology astatine nan UKB and personnel of nan Transdisciplinary Research Area (TRA) "Life & Health" astatine nan University of Bonn.

Interaction of nervus cells and electrical signals

While astir nervus cells ever fired astatine nan aforesaid oscillation time, immoderate nervus cells interestingly changed their preferred timing betwixt learning and remembering. "This supports nan mentation that our encephalon tin abstracted learning and retrieval processes wrong a encephalon wave, akin to members of an orchestra who commencement playing astatine different times successful a portion of music," says Guth. The study provides caller insights into really nervus cells and electrical signals successful nan encephalon interact while caller memories are formed.

A amended knowing of these processes could thief america successful nan agelong word to amended understand representation disorders and dainty them much effectively. "

Prof. Dr. Lukas Kunz, caput of nan Cognitive and Translational Neuroscience moving group astatine nan Clinic for Epileptology astatine nan UKB

The investigation squad was capable to observe nan relationship betwixt nervus cells and encephalon waves during nan representation process successful nan study by exploiting a typical characteristic of epilepsy therapy. Patients pinch peculiarly difficult-to-treat epilepsy person electrodes implanted successful their brains for diagnostic purposes. The purpose is to find nan nonstop root of nan epileptic seizures successful bid to execute amended surgical results. However, these implanted electrodes tin besides beryllium utilized to grounds quality encephalon activity astatine nan level of individual cells. The researchers utilized measurements taken astatine nan Medical Center - University of Freiburg and would for illustration to convey each patients who participated successful this study.

Source:

Journal reference:

Guth, T. A., et al. (2025). Theta-phase locking of azygous neurons during quality spatial memory. Nature Communications. doi.org/10.1038/s41467-025-62553-9.

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