Androgen Deprivation Therapy Lowers Satisfaction After Penile Prosthesis Surgery

Prostate crab is nan astir communal malignancy among men, pinch complete 160,000 caller cases diagnosed annually successful nan United States. Although advances successful surgery, radiotherapy, and hormone therapy person extended survival, these treatments often consequence successful complications that effect value of life. Erectile dysfunction, reduced libido, and changes successful intimacy stay communal and distressing, affecting some patients and their partners. Androgen deprivation therapy, successful particular, has been shown to triple nan consequence of erectile dysfunction and importantly trim intersexual satisfaction. While penile prosthesis room provides a restorative option, small is known astir its effectiveness successful men antecedently treated pinch hormone therapy. Based connected these challenges, location is simply a request for in-depth investigation connected inflatable penile prosthesis (IPP) outcomes successful nan discourse of androgen deprivation therapy (ADT).

Researchers from nan University of Texas McGovern Medical School, Hamad Medical Corporation, and MD Anderson Cancer Center published their study (DOI: 10.1002/uro2.116) connected February 19, 2025, successful UroPrecision. The investigation focused connected whether androgen deprivation therapy (ADT)—commonly prescribed alongside room aliases radiotherapy for prostate cancer—affects diligent restitution aft inflatable penile prosthesis (IPP) surgery. By comparing restitution scores betwixt men who had undergone ADT and those who had not, nan study provides important caller insights into really hormonal therapy shapes semipermanent intersexual outcomes for prostate crab survivors.

The squad conducted a retrospective reappraisal of 529 cases treated betwixt 2017 and 2022, identifying 96 prostate crab survivors who had received IPP room and completed nan Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire. Patients were divided into 2 groups: those pinch anterior ADT and those without. Findings showed that men pinch ADT reported importantly little restitution scores (p = 0.0344). Independent of hormone therapy, men treated pinch extremist prostatectomy mostly reported higher restitution than those treated pinch radiation therapy. Coronary artery illness was besides linked to little satisfaction, suggesting comorbidities further power outcomes. Researchers propose that ADT reduces restitution by suppressing testosterone, which not only targets prostate crab cells but besides weakens penile tissue, starring to atrophy and diminished elasticity. This physiological effect apt explains little scores among ADT patients. Radiation therapy patients besides had poorer results owed to progressive vascular damage, while extremist prostatectomy patients tended to use much from prosthesis surgery. These results underscore nan value of considering curen history, comorbidities, and hormonal position erstwhile evaluating erectile dysfunction solutions.

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Journal reference:

Jacob, J., et al. (2025). Effect of hormonal therapy connected restitution rates aft penile prosthesis room successful prostate crab survivors. UroPrecision. doi.org/10.1002/uro2.116