Acute And Chronic Stress Produce Distinct Behavioral Effects In Male And Female Rats

It is good established that accent tin summation susceptibility to various neuropsychiatric disorders, specified arsenic slump and anxiety, which are highly prevalent worldwide and correspond a important economical load and nationalist wellness rumor successful our society. The World Health Organization estimated that successful 2019, astir 970 cardinal group globally - 1 successful 8 - suffered from a intelligence disorder.

Evidence besides points to activity differences successful nan prevalence of and responses to stress. In fact, while women relationship for two-thirds of patients pinch stress-related disorders, different parameter shows that much than two-thirds of termination victims are men.

Although accent is simply a portion of life and, successful mini doses, tin moreover beryllium beneficial, excessive exposure, whether acute aliases chronic, tin person profound antagonistic effects, particularly connected nan brain, perchance starring to cerebrovascular diseases. One of nan astir delicate targets of excessive accent is nan blood-brain barrier, a building that protects nan encephalon from perchance harmful substances.

However, contempt grounds suggesting that different types of accent tin discuss its integrity and trigger neuroinflammatory responses associated pinch various neurological conditions, nan cellular and molecular mechanisms underlying these effects stay poorly understood.

In nan article "Distinct behavioral and neurovascular signatures induced by acute and chronic accent successful rats", published successful September successful nan technological diary Behavioural Brain Research, a investigation squad from nan University of Coimbra, Portugal, led by Ana Paula Silva, sought to explain this rumor by analysing nan effects of acute and chronic accent successful rodents.

With support from nan BIAL Foundation, nan researchers utilized unfastened section and forced swimming tests to measure locomotor activity and anxiety- and depression-like behaviors successful antheral and female Wistar rats.

The results showed that acute accent induces anxiety-like behaviors, particularly successful males, while chronic accent is much associated pinch depressive symptoms. Additionally, changes were observed successful cardinal proteins of nan blood-brain barrier, pinch important activity differences.

The investigation confirmed that acute accent and alleged chronic mild unpredictable accent induce chopped behavioral and biochemical profiles, highlighting nan value of differentiating accent types and considering biologic variables, specified arsenic sex, successful neuroscience research.

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Journal reference:

Simões, D. M., et al. (2025). Distinct behavioural and neurovascular signatures induced by acute and chronic accent successful rats. Behavioural Brain Research. doi.org/10.1016/j.bbr.2025.115706.